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A hand sprinkling pepperoni onto the Meat Lovers Pizza

Meat Lovers Pizza Casserole

Faster, cheaper, and 40% more protein-packed than delivery pizza, this Meat Lovers Pizza Casserole is a cheesy, meaty comfort food revolution. Great for busy families, keto dieters, and meal preppers!
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Prep Time 15 minutes
Cook Time 25 minutes
Total Time 40 minutes
Servings: 8 servings
Calories: 420
Ingredients Method Notes

Ingredients
  

  • 1 lb ground beef sub with plant-based crumbles for vegetarian
  • 1 lb ground Italian sausage spicy or mild; turkey sausage works!
  • ½ cup cooked turkey bacon optional but highly recommended for smoky depth
  • 2 cups marinara or pizza sauce opt for low-sugar or homemade
  • ½ cup sliced pepperoni turkey or beef—extra crispy if pan-fried first!
  • 2 cups shredded mozzarella go part-skim for fewer calories
  • ½ cup shredded cheddar sharp cheddar adds a tangy punch
  • ½ cup chopped green bell peppers adds crunch; omit for keto
  • ½ teaspoon garlic powder
  • ½ teaspoon onion powder
  • ½ teaspoon dried oregano
  • ½ teaspoon crushed red pepper flakes optional
  • ½ teaspoon salt
  • ½ teaspoon black pepper
  • fresh parsley or basil for garnish

Method
 

  1. In a skillet over medium heat, cook ground beef and Italian sausage until caramelized (about 8 minutes). Drain 90% of the fat, keeping a little for flavor. Stir in garlic powder, onion powder, oregano, red pepper flakes, salt, and black pepper.
  2. Pour in marinara sauce and let the mixture bubble gently for 5 minutes to meld the flavors.
  3. Grease a 9x13-inch baking dish. Spread half the meat sauce, sprinkle with 1 cup mozzarella and ¼ cup cheddar. Repeat layers. Top with pepperoni, bacon, and bell peppers (if using).
  4. Bake in a preheated 375°F oven for 20–25 minutes, until the cheese is bubbly and the edges are golden and crisp.
  5. Sprinkle with fresh parsley or basil and let cool for 5 minutes before serving.

Notes

For keto: omit bell peppers and use zucchini slices or cauliflower rice instead. For a vegetarian version, use plant-based meat and vegan pepperoni. Store leftovers in the fridge for up to 4 days or freeze up to 3 months. Reheat with a damp paper towel in the microwave to preserve cheese texture.