Why Make This Recipe
Cajun Chicken with Creamy Cajun Alfredo Penne is the perfect dish for those busy weeknights when you crave something hearty yet comforting. It’s a delightful mix of tender chicken, zesty Cajun flavors, and a luxuriously creamy sauce that coats every penne pasta piece. Not only is this recipe quick and easy, but it’s also packed with flavor that will have everyone at your dinner table asking for seconds. Trust me, once you try it, this will become a go-to recipe!
How to Make Cajun Chicken with Creamy Cajun Alfredo Penne
Ingredients:
- 1 1/2 lbs boneless skinless chicken breasts, cut into bite-sized pieces
- 1 1/2 tsp Cajun seasoning
- 1/2 tsp smoked paprika
- 3/4 tsp salt
- 1/2 tsp black pepper
- 2 tbsp olive oil
- 2 tbsp butter
- 4 cloves garlic, minced
- 14 oz penne pasta
- Salt for boiling water
- 3 tbsp butter (for the sauce)
- 3 cloves garlic, minced (for the sauce)
- 1 1/2 cups heavy cream
- 4 oz cream cheese, softened
- 1 1/4 cups grated Parmesan cheese
- 3/4 cup shredded mozzarella cheese
- 1 tsp Cajun seasoning (for the sauce)
- 1/2 tsp white pepper
- 1/2 tsp salt (for the sauce)
- 1 tbsp chopped fresh parsley
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Directions:
- In a bowl, season the chicken pieces with Cajun seasoning, smoked paprika, salt, and black pepper.
- Heat olive oil and butter in a skillet over medium heat. Add the minced garlic and sauté until fragrant.
- Add the seasoned chicken and cook until browned and cooked through. Remove the chicken from the skillet and set it aside.
- Cook penne pasta in salted boiling water according to package instructions. Drain and set aside.
- In the same skillet, melt 3 tablespoons of butter for the sauce, then add garlic and sauté for another minute.
- Stir in the heavy cream, softened cream cheese, Parmesan cheese, mozzarella cheese, Cajun seasoning, white pepper, and salt. Mix until smooth and creamy.
- Add the cooked pasta and chicken to the sauce, tossing everything to combine well.
- Serve hot, garnished with chopped parsley.
How to Serve Cajun Chicken with Creamy Cajun Alfredo Penne
Serve this delicious dish hot, straight from the skillet! I recommend adding a sprinkle of extra parsley for a pop of color. Pair it with a simple side salad or some steamed vegetables for a balanced meal. A slice of crusty bread wouldn’t hurt either – perfect for soaking up that creamy sauce!
How to Store Cajun Chicken with Creamy Cajun Alfredo Penne
If you have leftovers (which is rare, but it happens!), you can store them in an airtight container in the refrigerator for up to 3 days. To reheat, simply warm it up over low heat on the stove, stirring occasionally. You might need to add a splash of water or cream to loosen the sauce.
Tips to Make Cajun Chicken with Creamy Cajun Alfredo Penne
- Adjust the spice level: If you prefer it spicier, feel free to add more Cajun seasoning or even a pinch of cayenne pepper.
- For a lighter version, you can use half-and-half instead of heavy cream.
- Don’t rush the browning process of the chicken – it adds so much flavor to the dish!
Variation (if any)
Feel free to toss in some veggies like bell peppers or spinach for added color and nutrition. You could also swap the penne for another type of pasta, like fettuccine or even spiralized zucchini for a low-carb option.
FAQs
Can I use frozen chicken for this recipe?
Yes, you can use frozen chicken. Just make sure to thaw it completely and pat it dry before seasoning.
Is this dish kid-friendly?
Absolutely! The creamy sauce and subtle spices make it appealing to kids and adults alike.
Can I make this recipe in advance?
While it’s best served fresh, you can prepare the chicken and sauce separately a day ahead, then just cook the pasta and combine everything when you’re ready to serve.

Cajun Chicken with Creamy Cajun Alfredo Penne
Ingredients
Method
- In a bowl, season the chicken pieces with Cajun seasoning, smoked paprika, salt, and black pepper.
- Heat olive oil and butter in a skillet over medium heat. Add the minced garlic and sauté until fragrant.
- Add the seasoned chicken and cook until browned and cooked through. Remove the chicken from the skillet and set it aside.
- Cook penne pasta in salted boiling water according to package instructions. Drain and set aside.
- In the same skillet, melt 3 tablespoons of butter for the sauce, then add garlic and sauté for another minute.
- Stir in the heavy cream, softened cream cheese, Parmesan cheese, mozzarella cheese, Cajun seasoning, white pepper, and salt. Mix until smooth and creamy.
- Add the cooked pasta and chicken to the sauce, tossing everything to combine well.
- Serve hot, garnished with chopped parsley.